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#TestingMethods2020

Desktop PCR equipment for Point Of Care testing

33 Ideas
96 Votes
361 Comments
134 Subscribers

Taking samples and transporting them to testing labs takes time and may not always represent the best approach within clinical pathways. We are looking for the potential to add testing capacity through reliable and standards based testing at the point of care with desktop PCR machines that allow for fast, accurate and safe results for the operator.

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B: One to watch

AVPaT - Automated Virus Pathology (Dry) Testing in the Field using Artificial Intelligence neural networks and nano microscope

The AVPaT is a dry testing device approximately the size of a desktop printer, making it ideal for use in the field (Hospital wards, GPs etc). It combines Artificial Intelligence and a Nano microscope to provide rapid testing (results in under 5 seconds) for antigens or antibodies. AVPaT can tell operators whether the individual is infected, or has been, and with that what stage of the infection they are at, or the level of immunity they have. It has a 98+% specificity for antigen...

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B: One to watch

Developing an aptamer binder selective for the spike protein in SARS Cov-2 which we expect to complete in 3-4 weeks submitted by Peter Cousins

We’ve started a project to develop an aptamer binder selective for the spike protein in SARS Cov-2 which we expect to complete in 3-4 weeks.  Our aim is to work this into a point-of-care test for the SARS Cov-2 virus detection in saliva samples in 10 minutes, omitting the need for lab-based PCR testing for the virus, massively scaling up the number of virus tests that can be conducted. We plan to have a proof-of-concept device ready to scale up in two months. This isn't a  PCR...

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B: One to watch

Sensitive fluorescence based POC test for the rapid detection of COVID-19

We can offer fluorescence based detection of the presence of the SARS-CoV-2 virus using a lateral flow cartridge and a dedicated hand-held reader. Analysis is completed within 10 minutes of sample collection. The lateral flow cartridge is based on our current technology, included in products which are used to detect drug metabolites in the sweat of a fingerprint. We are applying our technology to detect the virus in nasal/oral samples and ultimately within the sweat of a fingerprint. The...

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D2

All in One Instrument for Extraction and qPCR detection of COVI19 virus

The system has been fully validated with CE and IVD being assigned in Germany, China, South Korea The AIGS system accommodates 4 individual cartridges containing reagents for extraction of the virus and qPCR detection. Patient sample(from buccal swab, lavage etc) is added into the top of the cartridge with magnetic beads; the cartridge is then placed into the instrument. A result is generated in 1 hour 30 minutes for 4 samples. 24 of the instruments can process 96 samples in 1 hour 30...

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E: A connection is helpful

sudo rtPCR Ultra high throughput + Non clinical mass surveillance testing.

It is pretty clear from the Mega labs that using slow methodical clinical  equipment  will  severely  rate limit any purposeful  surveillance testing.  Just not enough abi7500's in the country or world. The abi7500's in the Mega labs cant go to 384!. Need to be way above 200,000+ Just hitting 100k is not enough to accurately come out speed up slow down lock down.  End point pcr is hugely scalable. Kbioscience/LGC processed 1.5 million PCR's per day for gene absence/presence testing....

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Closed
A: Not for current challenges

Bio Sensor

Biosensor is a small (USB size) and easy-to-use product designed to test different biomolecules in saliva. B iosensors are not pure saliva collection tools, but built-in nanoelectronic sensor chips to detect biological indicators, as long as the chip is licked to get the results.  The nanochip is embedded in a paper card with a built-in  NFC  , which can immediately transmit the test results to a smartphone.  Each  B iosensor can perform multiple detections at once, detect...

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E: A connection is helpful

Revolutionising sample tracking – from swap to analyser to results

Electronic tracking of samples taken from remote locations such as roadside to testing centres. Analyser ready label printing at the roadside. Electronic transmission of data via HL7 messages to LIMS or other relevant systems from the remote location.   Leading to : More efficient planning of laboratory resources. Elimination of manual process errors which typically account for 6% of other samples such as blood. Reduction in lab time taken due to automatic printing of documents...

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B: One to watch

A Smartphone-based Rapid Handheld Point-of-Care Test for SARS-CoV-2 with Real Time Surveillance.

Dr. Pantelis Georgiou and his team at Imperial College London have developed Lacewing, a smartphone-based handheld point-of-care test for rapid detection of infectious diseases. https://twitter.com/lacewingcbit   This uses a semiconductor-based lab-on-chip device able to rapidly identify the virus that causes Covid-19 (SARS-CoV-2) from nasopharyngeal samples, utilising an isothermal nucleic acid assay for on-chip real-time detection with high sensitivity and specificity in under 30...

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Closed
A: Not for current challenges

Lyophilized COVID19 Diagnostics

Freeze drying COVID 19 diagnostic products in tubes, well plates and vials can help to stabilise the formulation as well as enhance the storage duration and reduce the complexity of shipping.

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E: A connection is helpful

Automated reporting and interpretation of COVID-19 results using machine learning AI- Increasing throughput capabilities, whilst maintaining quality standards.

We have a machine learning system (pcr.ai) for automated interpretation, monitoring and reporting of COVID tests which can be used to link PoC devices to central laboratories.  In under three minutes, results from any thermocycler are available for the patient. Patented AI ensures accuracy of results and standardisation ensures results from different equipment and labs can be compared - all in real-time. Complete QC monitoring further ensures reliability of results. Pcr.ai enables sample...

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