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#TestingMethods2020

Dry swabs for use in virus detection

15 Ideas
29 Votes
131 Comments
66 Subscribers

A key element of speeding up the end to end testing process is the availability of swabs that can be used easily and reliably to detect the virus in a range of different swabbing applications and age groups including for use in home testing and which can be used with multiple extraction platforms.

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B: One to watch

We have developed a rapid point of care device for Covid 19 from dry swabs. The result is available in minutes

We are currently undergoing ethics to validate the system

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11
A: Not for current challenges

Reprocess used Negative Swabs Swabs

If a swab proves negative for Covid 19 use it again. Could be sterilised by irradiation or some other method. I don't know if this could be extended to all swabs obviously you need to get rid of any RNA but that wont be on the negative ones.

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7
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B: One to watch

A simple, colour change based at-home diagnostic that is cheap and scalable

The idea relies on protein complementation technology, which is very well applied in life sciences research. Here we take advantage of camelid nanobodies that have recently been published ( https://www.biorxiv.org/content/10.1101/2020.03.26.010165v1 ) - these nanobodies bind to RBD domain of CoV S protein. Since S protein is a trimer, 2 nanobodies can bind each S trimer. So, by genetically engineering two constructs - one with nanobody fused to one half of the split enzyme, and other...

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8
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Additional information

Rapid remote COVID-19 testing: a convenient and accessible testing alternative

SH:24 is a multi-award winning health tech company, delivering online sexual and reproductive health services across the UK, 24:7. We offer a range of services including home STI testing, treatment, remote diagnosis, contraception, interactive sexual health risk assessments, all supported by unrivalled specialist clinical advice and support. Having delivered over 300,000 tests in the past year, we are seen as the leading STI test provider and are fully integrated into the NHS. Using our...

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12
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Additional information

drySWAB viral transport system

We do have results comparing stability to the currently used Viral Transport Media: 1. No need for cold chain logistics. ship and store at ambient temperature. 2. longer ambient temperature stability 3. No sample dilution effect. control over liquid sample volume used for diagnostic assay

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6
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Closed
A: Not for current challenges

CoV-2 Antibody Test

My expertise is in medical devices. This test was proposed to me last month by my trusted partner in China. As I do not have the expertise to assess its credibility, I did not proceed. If, however, such a test, or components of the kit, could be of use I would happily request further information from the supplier.

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4
Closed
A: Not for current challenges

Can we use the properties of SARS CoV2 to help choose simple to use swabs and swabbing procedures?

SARS CoV-2 and related coronaviruses have been shown to have a significant and persistent half life (up to 9 days) on a number of material surfaces particularly stainless steel but also a variety of plastics Including polypropylene,Teflon, PVC. (1,2) at ambient temperatures. Can this property be exploited to enable the use of very simple and widely available swabbing materials e.g. polypropylene rods or strips or pvc sheets or strips? For simple non quantitative tests which need to...

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5
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Additional information

OM-505 and OR-100 devices - currently being tested in the USA

No I haven't. However, I have contacted the company DNA Genotek and this is one of the answers I received: "We do have more information regarding our kits and their use in COVID-19 testing including some relevant documentation, the account manager can connect with you to discuss these." "However we do not yet have data on samples collected with our devices. We do know that our stabilization solution can accommodate a very broad spectrum of microbiome activity spanning bacteria to...

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6
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Mail sterile kits with plastic pasteur pipettes and RNAlater or RNAstable eppendorfs to public [MOVED: see link below for idea]

Idea moved. See here:  https://testingmethods.crowdicity.com/post/3232040          

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15
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D2

Dry swab and test medium provided with one tube COVID kit and validated

The swab and transport media are part of our complete one tube kit (posted under RNA extraction challenge). The IFU states for swabbing: "after rotation/sample collection" quickly put into specimen collection tube containing lysis buffer (proprietary) or sample storage reagent containing RNA inhibitor. Insert swab, then break the sterile swab near rod near the top, tighten tube cap and seal with sealing film".  Specimens to be tested can be immediately processed, stored at 4C if...

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7
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