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#TestingMethods2020

Alternatives to Swabs for Sampling

16 Ideas
0 Votes
75 Comments
26 Subscribers

One of the significant constraints on current testing capacity is availability of swabs for sampling. We are looking for alternative non-swab based methods or techniques of sampling for the virus that have been used in other applications or contexts and that can be implemented rapidly. Examples could be, but not limited to, use of saliva, faeces and potentially urine.


We also welcome ideas related to non-blood based sample collection for antibody testing in this challenge.

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D2

At-home collection using a donor friendly method of saliva sampling

Our expertise is in human genomics and microbiome sampling through saliva. Saliva is a less intrusive method of COVID-19 testing, arguably more sensitive and it doesn't require a health care worker to be present / PPE. We're working with a number of groups across the world that are validating these devices due to the ability to process in high-throughput workflows. This is not an end-end service; however, we know labs capable of the processing. 

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E: A connection is helpful

Breathalyser – Freedom of Movement and Virus Control

The proposal recommends a modified breathalyser to enable frequent self-testing.  The breathalyser could export the result as a QR code into a mobile phone (or alternative) and date stamped. This then can becomes part of a wider overall solution that would use QR scanners at any location where people need entry. This overall solution facilitates return to free movement as well as identifying those that need medical intervention. The f ull proposed solution is attached.

4
A: Not for current challenges

Covid-19 Scent Dogs

Sniffer dogs are used worldwide in industry for the detection of drugs, explosives and even items as specific as USB sticks. They are also used for medical detection, detecting cancers and malaria in addition to providing individuals with pre-warning of epileptic seizures and hypoglycemia. Dogs have now been proven by the University of Helsinki to be able to detect SARS-CoV-2 in a laboratory environment using urine. They can detect the virus up to 5 days before symptoms emerge and can...

2
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A: Not for current challenges

High accuracy rapid Covid-19 test, manufactured in Germany

Rapid Test is a chromatographic lateral flow immunoassay for the qualitative detection of anti-SARS-CoV-2 IgG and IgM in human whole blood, serum or plasma samples. It is important to note that in the early stages of the infection (3 to 7 days after symptoms first appear), anti-SARS-CoV-2 IgG and IgM may be below the detection limit of the test. The test is intended as an aid in the diagnosis of primary infections and possible secondary infections with SARS-CoV-2. The test procedure is not...

2
A: Not for current challenges

Rapid testing via finger prick

We currently have the availability to test for the IgG & IgM antibody via finger prick to results cassette rather than swab and PCR based testing.  This way of testing has been approved bt the FDA in the USA and also is being used in Canada, Spain and Netherlands.  The Rapid based test would be a great way f training people that are positive for the IgM antibody and then we could focus the swabs on to the people that actually need the service, thus limiting the requirement for such a...

2
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B: One to watch

Viral inactivation and concentration through a method of faecal filtration, for the safe testing of patient samples using PCR or EIA methods.

Apacor’s Parasep faecal concentration devices are marketed worldwide as the leading pre-analytical method for faecal filtration and parasite concentration. By utilising a patented vertical filter design, these devices are able to separate and concentrate parasitic ova/cysts from faecal matter through a simple centrifugal process.   Apafix is a patented universal fixative able to effectively neutralise parasites within a sample, whilst retaining complete capacity for PCR and EIA testing...

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D2

Mass swabbing using GoodSAM network & Gamma radiated FDA approved Q tips.

Swab samplings the killer as we all know. Tubes have to go out and come back with zero packaging. Amazon etc already have bar code scanners but they got a day job.. Uber now going back to work.. So how ?  Well there are 750,000 GoodSAM nhs volunteers sitting at home doing nothing!. I know I’m one of them. . Then there are two levels of NHS volunteers ones that are more medical competent who trained in defib etc  Both these could be utilised to expedite getting samples to houses and back in...

6
E: A connection is helpful

Breath Test as alternative to swabs

Throat and nasal swabs are unreliable it is difficult to take reliable samples especially with self testing and the only reliable result is therefore a positive ! As the Coronavirus seems to primarily affect the lungs I suggest taking something like a drinking straw which has a cotton wool swab or capture membrane embedded within the straw. The patient  blows through the straw similar to a breathalyzer sample and the virus particles which present in aerosols from the lungs and throat  are...

5
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A: Not for current challenges

Peezy Midstream right-first-time urine collection, analysis, diagnosis, treatment

Clean catch midstream urine collection Reduced contamination and false positives Improved accuracy of diagnosis Sample delivered in lab-compatible tube (no decanting) Reduced burden on labs Reduced prescribing Improved infection control Significant cost savings to NHS Improved hand hygiene Excellent clinical evidence Overview Peezy Midstream is designed for easy, non-touch urine collection by patients, ideal for primary care and antenatal settings in particular. It...

3
A: Not for current challenges

Using the Measurable Changes in Skin Conductivity Caused by the Introduction of Unique Electromagnetic Signatures to Verify the Presence of Covid-19 (and any other pathogen) in the body

Principle Behind the Test: Based on the precept that everything has a unique electromagnetic signature, it is possible to easily confirm the presence of any pathogen (in this instance Covid-19). By measuring skin conductivity both before and after the introduction (of an inert sample) of the Covid-19 virus it can be determined whether the virus was already present or was introduced. If Covid-19 was already present then, logically, the introduction of more Covid-19 should not change...

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