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Breath-test for LAMP technology

E: A connection is helpful

This is an idea - to simplify safe sampling for COVID 19 screening, particularly community screening, LMC and remote community use.  I wonder if we could develop a filter device for exhaled breath. Filter not dissimilar to the concept of a cigarette filter but  filtering capacity designed to capture, neutralise and concentrate exhaled viral particles for direct inclusion in a LAMP test tube. Very much depends on evidence for exhaled air as a reliable COVID transmission route.  An individual would exhale through the filter that would then be placed directly into the LAMP assay tube for on-site testing. 

Have you validated this method, if so, how and what were the results of the validation?​

No this is to float as an idea for COVID  rtLAMP developers

How quickly could this be deployed and what are the dependencies?​

should be fairly low tech but depends on exhaled viral load

What is the likely production volume?​

high

What are the risks and barriers to using this at scale?​

if the filtration unit can immobilise and neutralise exhaled virus would be extremely safe and easy to use,

Who are you already partnering with on this?

No one - simply an idea that I had today when discussing LAMP technology - I do not see this effort as a race, or money generating, or career enhancing or any other glory exercise but only towards a gigantic not-for-profit global collaboration for the benefit of humanity. 

Janet Cox-Singh

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Kathryn Perera Apr 13, 2020

Hi Janet, thanks for sharing this idea. Please keep ideas coming as you continue discussions on LAMP technology.

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Janet Cox-Singh Apr 15, 2020

Hi Kathryn, for what its worth I think LAMP type technology is the way forward - and if we had a safe non-invasive sample collection method would be a perfect partnership for wide-spread use all settings.

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Kyle Beacham Apr 14, 2020

Status label added: B

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Kyle Beacham Apr 14, 2020

The idea has been progressed to the next milestone.

Reply 0

Janet Cox-Singh Apr 15, 2020

Hi Kyle,
I am not sure what to do next - I am almost certain such a small filter can be adapted from some other use - clean room, air cleaning systems, diving, some other lab utility - the crux is viral particle number in exhaled breath - would there be enough viral particles for example in someone with a small viral load? Also would need to capture, concentrate, neutralise in a form allowing nucleic acid availability to LAMP

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Bev Matthews Apr 25, 2020

Hello Janet, our reviewers have identified this solution may benefit from connection with the Breathomics Group - i will connect you by email as soon as i have the key contact. Thank you Bev

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Luke Wainwright 11 months ago

Dear Janet,

Further to Bev's correspondence, for now, we would recommend speaking with the East Midlands Breathomics Pathology Node (EMBER) to progress your idea:

https://ember.le.ac.uk/web/

With kinds regards,

Luke

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Bev Matthews Apr 25, 2020

Status label added: E

Status label removed: B

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Luke Wainwright 11 months ago

The idea has been progressed to the next milestone.

Reply 0

Janet Cox-Singh 11 months ago

Hi Luke, thank you for this - I will make contact with EMBER

Reply 0

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