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Precise control of SARS-CoV-2: Endpoint and pooled sequencing

With the current SARS-CoV-2, mutational evolution and escape will happen in response to native immunity and vaccine induced immunity.

We need to move from individual test, track and trace to community based active sampling of boroughs/postcodes/households. 

Weekly swabbing, pooled or endpoint RNA / sequencing; and targeted quarantine with antibody surveillance of positive pools or households. 

Mass vaccination in a staggered manner only increases the risk of sequential vaccine escape mutants. It is better to stabilise the virus phylogeny and mass vaccinate those who who are antibody negative.

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